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Nicotine fulfills all the criteria of an addictive agent, including psychoactive effects, drug-reinforced behavior, compulsive use, relapse after abstinence, physical dependence, and tolerance

These findings matter because the tobacco industry routinely targets young people in an effort to create lifelong smokers

Manufacturing of smoked tobacco products: The processes, materials, and techniques to manufacture different types of smoked tobacco products such as cigars, fine cut tobacco, pipe tobacco, and cigarettes

Younger generations were gravitating toward vape pens due to their flavoring and the suggestion of the product being a safer option

Having a brand at each tier means ITC can capture customers up the value chain and prevent competitors from finding a niche

Supplementary material The Supplementary material for this article can be found online at: Footnotes 1.^In November 2018, FDAs commissioner made an initial statement proposing new steps to reduce youth access to ENDS, including reducing access to flavored ENDS (other than mint, menthol, tobacco) (U.S