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monnieri gave a substantial improvement compared to Alzheimer's patients treated with donepezil, returning the depression score close to that of the healthy aged adults

Da Silva, R

The activation of macrophages and the subsequent release of proinflammatory cytokines can lead to a cascade of neuroinflammatory processes affecting neurotransmitter systems

Notably, deletion of GPX4 caused severe phenotypic abnormalities in mice in animal experiments, whereas deletion of the ALOX12 gene did not cause major developmental defects in mice

One enzyme, CSE, supports the biosynthesis of persulfides, primarily by generating H 2 S from Cys, but potentially also by generating cysteine persulfide from cystine 14

These are all known drug targets