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7.3 Treatment strategies Calcium channel blockers and opioid antagonists, such as naltrexone, have shown potential for managing heroin addiction and ischemic stroke ( 7.4 Comparative analysis: cocaine and heroin Although cocaine and heroin have profound neurobiological and vascular effects, their mechanisms of action differ significantly

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Poor sleep impairs tissue repair, elevates inflammatory markers, and lowers pain tolerance all of which directly impact foot and ankle conditions

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