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In the presence of transition metal ions, ROOH can give rise to the generation of radicals capable of re-initiating lipid peroxidation by redox-cycling of these metal ions (Halliwell & Gutteridge, 1984)

17 (1), sfad137

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To this point we used a blunted generation of NO-pathway (NOS-blocker, L-NAME), an (over)-stimulated NO-system (NOS-substrate, L-arginine), and NO-system immobilized (in which L-NAME + L-arginine would antagonize each others responses to confirm specific NO-system involvement) (10, 45, 46)