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Reference: Gorouhi F & Maibach HI (2015)

Regarding excretion, CoQ10 had the greatest total clearance, indicating fast elimination, which might require repeated administration or formulation approaches to maintain the action

To achieve budget neutrality for these proposed changes in the GAFs, we calculated an incremental GAF budget neutrality adjustment factor of 0.9977 for FY 2024

Strengths and limitations One of the major strengths in this review demonstrates the overall low risk of bias with no studies having ranked less than good (PEDro score)