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De novo NAD+ synthesis enhances mitochondrial function and improves health

Fratini A, Powell BC, Hynd PI, Keough RA, Rogers GE

A study on peripheral nerve injury demonstrated that hypoxia suppresses ferroptosis in dorsal root ganglion (DRG) neurons through HIF-1 activation, which upregulates the expression of SLC7A11 and GPX4 and increases intracellular cysteine and glutathione levels (Qian et al., 2025)

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We further found that the disrupted methionine cycle and dampened transsulfuration pathway resulted in decreased cysteine levels in the liver, which ultimately contributes to GSH unavailability in chronic alcoholic liver injury

( b ) CAR-T cells are viable up to 20 days post-retroviral transduction for donor 6