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In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels

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Most of these effects appear to outperform placebo

Doctors usually prescribe B12 shots for genuine deficiencies like pernicious anemia or malabsorption disorders

We assumed that a physician visit to explain to patients the benefits of oral therapy and instructions for use would take place on the day they came in to receive their intramuscular injection, and so this visit was not added to the conversion cost

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