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Excessive Fe 2+ is oxidized to Fe 3+ by ferroportin (FPN) to maintain intracellular iron homeostasis (Gao et al., 2015), while heme oxygenase-1 (HO-1) supplementation accelerates erastin-induced ferroptosis (Kwon et al., 2015)

10.7554/eLife.27055 Elife 45 CrtesN.LiraA.SilvaJ.CarvalhoE.Prates-SyedW.HamaguchiB.et al

Our data encourages incorporation of oxidative stress and metabolic parameters in immune cells, particularly NK cells, as investigative endpoints.in future investigations of LSD1 inhibition

Towarnicki, S

However, in chemotherapy-resistant ovarian cancer patients (NCT00345540), NOV-002 in combination with carboplatin failed to reach its aim, and thus was withdrawn [63]