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I commonly use diindolylmethane (DIM) and sulforaphane from cruciferous vegetables to encourage healthy 2-hydroxylation of estrogen, calcium-D-glucarate to support glucuronidation, magnesium and methylated B vitamins for methylation, and glutathione to help neutralize reactive estrogen metabolites

Steroids In the course of treating epileptic encephalopathy or infantile spasms, treatment with high-dose steroids may help

Mass Spectrometry Confirms molecular weight and verifies compound identity through advanced analytical techniques

If your body is overly sensitive with allergies and histamine reactions to anything and everything, a supplement like Histamine Relief may be helpful in getting things to calm to a point where other treatments can be helpful

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J Strength Cond Res 26:17241729