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Description

Chemical screening in zebrafish models showed that a histone deacetylase (HDAC) inhibitor MS-275 can facilitate hepatocyte-to-cholangiocyte (HC-to-CC) transdifferentiation after injury

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The generation of mutants for selected genes based on transcriptomic data, using advanced techniques such as CRISPR/Cas9, will further open new horizons for developing resistance to viruses or other multifactorial stresses