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The variation in C max within the normal renal function group was larger than the renal impairment groups owing to outlying profiles with low exposure

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Although sapropterin dihydrochloride is more expensive than a Phe-reduced diet and is still unavailable in some (European) countries, it enables a markedly higher natural protein intake and offers a much more convenient way to treat HPA

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Per injection: 5 mg twice weekly (10 mg/week total), drawn as ~100 units (1.0 mL)