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Pinnen F, Cacciatore I, Cornacchia C, Sozio P, Iannitelli A, Costa M, Pecci L, Nasuti C, Cantalamessa F, Di Stefano A

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2

The primary metabolites of PAD, such as quercetin and kaempferol, play a crucial role in this process

Mounting evidence positions redox imbalance not merely as a secondary phenomenon but as a primary driver of the disease continuum - from initial -cell dysfunction to devastating micro- and macro-vascular complications

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