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Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon

10.1038/nrm4043 71

Principles of Free Radical Biomedicine, Vol II 1st ed

Mechanistically, BL suppresses iNOS expression, stimulates prostaglandin E 2 production, impedes leukocyte migration, and attenuates Toll-like receptor-4 (TLR4)-mediated iNOS upregulation and interferon- (IFN-) secretion (Idelman et al., 2015