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The 24-h Uox values for three of the five patients who received 1.5 mg/kg of DCR-PHXC reached near-normalization levels at one or more postdose time points, and their mean maximal 24-h Uox reduction was 51% (range: 2872%)

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Gardiner CS, Salmen JJ, Brandt CJ, Stover SK: Glutathione is present in reproductive tract secretions and improves development of mouse embryos after chemically induced glutathione depletion