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Bioavailability is the measure of how much of a substance actually enters your circulation and is able to have an effect

Thiosemicarbazones functioning as zinc metallochaperones to reactivate mutant p53

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As seen from Figure 3A (gray bars), the GSH decrease becomes insignificant in the thiamine-treated LE and SCI animals, compared with the non-operated control animals, whose GSH content is independent of thiamine