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TDP-43 K408R mouse line generation At The Centre of Phenogenomics (SickKids, Toronto, ON, Canada), the TDP-43 K408R mice were generated on a C57BL6/N background based on previous methods [117] using CRISPR/Cas9-mediated gene editing of the endogenous Tardbp locus

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In younger adults, pineal calcification is typically less advanced and melatonin production remains adequate, so the age-restoration rationale is less relevant

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doi: 10.1016/J.PROCBIO.2023.10.007 199

Cholesterol synthesis begins with acetyl-CoA in the cytosol