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Carotenoids exhibit biological activities such as anticancer, antidiabetic, antioxidant, antiallergenic, antiinflammatory, and antiangiogenic activities as well as helping in immune modulation [96, 97]

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects

10 Thus, this work is an important step forward, establishing that MCs, histamine, and H4R coordinate innate responses to drive clinical severity in IBD