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2020;140(3):574582.e2

Dietary essential fatty acids and brain function: a developmental perspective on mechanisms

Unbiased genome-scale gene perturbation screens have identified a critical role for the transcription factor Ikaros in supporting both RelA positive feedback and TNF production ( The complex relationship between NF-B dynamics and transcriptional control in macrophages was recently investigated further by coupling the dynamics of fluorescently labeled RelA with single cell RNA-seq ( While the amplitude of NF-B translocation to the nucleus can be correlated with inflammatory gene induction and sustained expression, multiple recent studies hint at the importance of the integration of multiple signaling processes ( Tnf transcription by activating NF-B through the canonical pathway ( Tnf promoter activity depends greatly on TRIF's involvement downstream of LPS stimulation ( Tnf (Figure 2)

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Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, et al

Here we show that depletion of intracellular GSH does not alter tumour growth and extracellular GSH is highly abundant in the tumour microenvironment, highlighting the potential importance of GSH outside tumours