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Noninvasive imaging methods calibrated to histological readouts would translate quantitative scoring approaches into clinical applications 48,49,50

If weight is the goal, track that separately from B12 correction and use interventions designed to create lasting fat loss

PMID: 22690265

Czabotar PE, Garcia-Saez AJ

reported that the novel aldehyde dehydrogenase 2 (ALDH2) activator, AD 9308, significantly enhanced both systolic and diastolic cardiac function in STZ-induced diabetic mice

Senapati J, Fiskus WC, Daver N, Wilson NR, Ravandi F, Garcia-Manero G, Kadia T, DiNardo CD, Jabbour E, Burger J, Short NJ, Alvarado Y, Jain N, Masarova L, Issa GC, Qiao W, Khoury JD, Pierce S, Miller D, Sasaki K, Konopleva M, Bhalla KN, Borthakur G , Pemmaraju N