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Most reasons are treatable or removable by proper diagnosis and drugs

Nat Chem Biol (2013) 9(5):3006

It targets the various steps responsible for causing acne, including inflammation, sebum production, abnormal keratinization, and colonization with Propionibacterium acnes

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Kikutani S, Nakajima K, Nagasato C, Tsuji Y, Miyatake A, Matsuda Y

Detailed and regular filling of the diary by the patient will help the doctor