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From the ASV table (Supplementary Table S1), sums of ASVs within each respective phylum or genus for each sample were calculated to establish the abundance of each phylum or genus per sample

As NAD+ supplementation research has expanded dramatically, the discovery that NNMT depletes NAD+ precursors specifically in metabolically dysfunctional fat tissue provides a targeted intervention point

Epitalon is a peptide therapy commonly incorporated into wellness programs designed to support healthy aging, cellular balance, and overall wellness

For this reason, its even more important as we age to talk to a doctor about whether or not our bodies are absorbing the vitamins we need

Its job is specific: it inhibits an enzyme called NNMT nicotinamide N-methyltransferase that becomes overactive in fat tissue, especially as we age

What was developed relatively recently is its repurposing and optimization as a cell-permeable NNMT inhibitor, not the compound as a chemical entity.