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Surprisingly, to prevent activated neutrophils from releasing their highly cytotoxic inflammatory mediators into the tissue environment and damaging surrounding tissues along the bloodstream, neutrophils spontaneously undergo apoptosis

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NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs

Activated TRI subsequently phosphorylates the downstream signaling molecule Smad, leading to its nuclear accumulation and transcriptional regulation as a transcription factor