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It is crucial to distinguish that the central energy deficit specifically refers to metabolic dysfunction within the central nervous system, impacting both neurons and glial cells (such as impaired glucose metabolism and mitochondrial dysfunction), rather than a deficiency in cerebral perfusion due to circulatory system dysfunction

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Medical complications of excessive alcohol use affect multiple organ systems (eg, gastrointestinal, hepatic [such as cirrhosis and alcoholic hepatitis], immune, endocrine, pulmonary, cardiovascular, hematologic, and neurological), and they can often lead to certain cancers, as well as to significant morbidity and mortality

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With this in mind, Stravalaci et al