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Two patterns are worth calling out because they are predictable rather than alarming

doi:10.1152/ajpendo.2000.279.3.E501 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

it does not reliably modify appetite-regulating circuits beyond baseline in healthy individuals

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doi: 10.1186/s12943-019-1029-8 112 ChengXDaiEWuJFloresNMChuYWangR