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Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species

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Growth retardation is assessed by the SDS or height deficit score, which measures the patients height in comparison with that of unaffected children of similar age

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In patients receiving cagrilintide 2.4 mg plus semaglutide, there was a mean body weight change from baseline of -17.1% compared to -9.8% with semaglutide alone

Also, SGLT2 inhibitors are suggested to modulate ROS- and TNF-mediated neuroinflammation and promote the production of neurotrophic factors including BDNF 54,64,65