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Dietary methionine receives an adenosyl group from ATP to form S-adenosyl-L-methionine (SAM)

During this process, tumor cells acquire invasive traits to dissociate from the primary tumor, migrate through surrounding tissues, and colonize distant organsa progression driven by dynamic interactions with immune, stromal, and extracellular matrix components (Zhao et al., 2023)

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Histone crotonylation refers to the addition of a crotonyl group to a lysine residue

In the absence of GSH synthesis, FoB upregulate mTORC1 and reprogram their metabolism towards glycolysis, which is similar to the metabolic program of wild-type MZB