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The deletion of CB 1 Rs from GABAergic neurons enhanced a phenotypic switch in astrocytes already associated with aging, including increased GFAP expression and amplified pro-inflammatory cytokine secretion in mice (Bilkei-Gorzo et al., 2018)

The compliance percentage was calculated using the following formula: ([total sum of prescribed vials the number of remaining vials at 12 weeks] / total sum of prescribed vials) 100

This evidence suggests a connection between immunosenescence and the diminished efficacy of ICB