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Description

Selenium: Tracing Another Essential Element of Ferroptotic Cell Death

H.NasirianF.NakanoK.WardD.PayM.HillR.et al (1995)

Research applications include investigations into NAD+ metabolism, mitochondrial function, and metabolic adaptation.

Mechanistically, PCK2-K100la augments its kinase activity and competitively inhibits the Parkin-mediated polyubiquitination of 3-oxoacyl-ACP synthase (OXSM), thereby altering mitochondrial fatty acid synthesis and boosting oxidative phosphorylation and the TCA cycle