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Tesofensine gained attention in obesity research due to clinical findings showing reduced food intake and meaningful body weight reductions in controlled trials

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Myeloperoxidase (MPO) activity, a marker for neutrophil infiltration, was measured in lung tissue homogenates using a previously described spectrophotometric method, assessing HO-dependent o-dianisidine oxidation

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[5] However, because it is not FDA-approved for therapeutic use in the United States, its administration is considered off-label or investigational, making medical supervision essential rather than optional