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PMI-sponsored researchers focused their efforts on chemical analysis and toxicity assessment, and studies related to health benefits for smokers switching to IQOS, generating data to support the IQOS MRTP application.11 18 The industry used exposure reduction as a feature to promote IQOS as a safer tobacco product than combustible cigarettes.99 100 On the other hand, independent research published 90 articles on perception, awareness, use and prevalence to highlight IQOS use trends and directions in the population.101103 Tobacco control experts are concerned with the widespread use of IQOS and its impact on individual and public health,104 so they reported comprehensively on IQOS emissions, toxicity assessment, health impact, and marketing and regulation