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ACS Infect Dis 6(7):15581562 Abraham EC, Taylor JF, Lang CA (1978) Influence of mouse age and erythrocyte age on glutathione metabolism

The closed form of ME2 is a pentary complex with natural product pyruvate, cofactor NAD + , Mn 2+ , and fumarate 3,43

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Knockout of circ0097009 lead to decreased expression of SLC7A11, inactivation of GPX4 and a decrease in GSH/GSSG ratio, all of which result in increased sensitivity to ferroptosis (175)