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Vincristine, a chemotherapeutic agent, is known to cause neurotoxicity by decreasing levels of the antioxidant protein Nrf2 and its downstream targets HO-1 and NQO1

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doi: 10.1016/j.psychres.2018.05.059 203 BazinetRPLayS

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Rapid mechanisms of glucocorticoid signaling in the Leydig cell

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1d), without any significant difference in body weight, food intake, or liver and kidney physiological functions (Fig

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For established cognitive support, the evidence-based options include aerobic exercise (strong evidence for cognitive benefits, especially executive function and processing speed), sleep optimization (critical for cognitive function), Mediterranean diet (modest evidence for cognitive protection over years), treating sleep apnea (significant cognitive improvements when this condition is addressed), treating depression (major cognitive effects when present), donepezil and other approved Alzheimer drugs (modest evidence-based effects in actual Alzheimer disease), and stimulants (well-established for ADHD)

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