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Environment dictates dependence on mitochondrial complex I for NAD + and aspartate production and determines cancer cell sensitivity to metformin

Both authors contributed to the article and approved the submitted version

Therefore, the strategic targeting of MDSCs to convert GBM from a "cold" tumor, refractory to immune response, to a "hot" tumor that responds favorably to immunotherapy holds significant therapeutic promise (Fig

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Reviewing the following with a licensed provider is an essential part of treatment