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It has been called the gold standard of prevention interventions by David Eddy, a leading authority on guidelines and cost-effectiveness analysis

[12] [Recurrent genital herpes] However, this preventive tool does not seem to be feasible in practice because of its monetary cost($1,440 per year on average with daily use), psychological burden(taking medicine daily), and potential side effects (nausea, dizziness, and abdominal pain)

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Chayka of Wisconsin."[69] [60] "Michigan's Cigarette and Tobacco Taxes 2001," Michigan Department of Treasury, 2006, 2