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Rating: 4.5229 (18 reviews)

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Description

Excessive dosages can sometimes cause more harm than benefit

A decline in the cellular GSH level is indicative of an ethanol-induced oxidative stress, which is characterized by the generation of toxic acetaldehyde and other reactive molecules in the cell

Resnitzky et al

10.1016/s0092-8674(00)81733-x Cell 325 ZhangC.ZhaoM.WangB.SuZ.GuoB.QinL.et al (2021)

Experimentally, mice with conditional knockout of GPX4 in the cortex and hippocampus exhibit profound spatial memory deficits and hippocampal neurodegeneration (189)