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The mice were maintained in microisolator cages on individually ventilated racks, with aspen chip bedding, in a controlled environment (temperature: 2022 C, humidity: 50%60%, 12-h light/dark cycle)

The mutant huntington may cause oxidative stress and neurotoxicity to the neurons in corpus striatum (Paul et al., 2014), which ultimately results in neuronal dysfunction and neuronal cell death, leading to patients with motor and cognitive impairments

It also is evidenced to cross the blood-brain barrier and is nearest in efficacy to IV glutathione than any other oral form

& Jang, Y.-Y

Each database was searched using combinations of the identified keywords, and the results were reviewed to identify studies and materials that were consistent with the research objectives