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On the other hand, it is well-found that in vivo, macrophage activation occurs along with pro-inflammatory and anti-inflammatory conditions, with a degree of flexibility in both directions (Yamada and Kielian 2019)

[0319] In some embodiments, the compositions comprise an anti-acne ingredient (e.g., salicylic acid)

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This process is fundamentally dependent on the activation of the AhR and subsequent upregulation of the autophagy-associated gene ATG5 (138, 139)

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