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Inhibiting the CLOCK-OLFML3-HIF-1-LGMN-CD162 axis demonstrates the potential to reduce microglial infiltration, enhance the infiltration, activation, and cytotoxicity of CD8 + T cells, and exhibit synergistic effects with anti-PD-1 therapy [309]

An observational study comparing permanent residents of La Rinconada (5100 m) and Puno (3800 m), both in Peru, revealed significant pathological changes in individuals living at the highest altitude

Moreover, zinc supplementation was suggested to support sustained remission and reduce relapse rates [137]

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However, the impact of miRNAs on the development of resistance to both ADT and chemotherapy is much broader and involves a variety of targets and mechanisms [108, 110]