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Upon intranasal administration, Methylcobalamin is rapidly absorbed through the nasal mucosa and enters the bloodstream, where it acts as a cofactor for enzymes involved in DNA synthesis and methylation

doi:10.1210/jc

Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association in two population studies with a tiny absolute event rate. Depression and suicidality remain unproven

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If untreated, congenital hypothyroidism can lead to intellectual disability and growth failurewhen a baby doesnt grow as expected

10.1007/s10787-017-0358-8 6 BonaE.HagbergH.LbergE