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ADH1B variants can cause a faster buildup of acetaldehyde

However, one should also keep in mind, that p53, generally activated in cellular stress controls, is also involvedbesides controlling the above mentioned metabolic pathwaysin other cellular key processes, like apoptosis, autophagy and cell proliferation through inhibition of Akt and mTOR (Liang et al., 2013)

Moreover, ROS-dependent angiogenesis can be induced through the activation of this pathway to lead to the expression of HIF1 and VEGF [45]

As well, MPTP, a widely used toxin, is effective in inducing Parkinsonism in both rodents and primates, based on its ability to induce persistent symptoms akin to PD in humans (Davis et al

Identification of novel risk and prognostic biomarkers may enable an individualized treatment pathway for patients with DPN from a potentially disease-modifying perspective, and provide onward opportunities for novel treatments that would be efficacious in early stages of DPN, and alter the natural course of the disease

Sources: Dixson et al