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Mechanisms of Central Auditory Damage The mechanisms that contribute to central auditory deficits associated with noise damage and aging have received much less attention than those underlying cochlear damage

doi: 10.3168/jds.2015-10157 93 OsorioJ

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation

But its ageing and damage beneath the skin thats arguably more important

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