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If cloudiness persists, allow vial to rest for 5-10 minutes and gently swirl again

If symptoms persist despite regular oral supplementation, absorption may be limited

Risks and Side Effects While B12 shots are generally very safe, you should be aware of a few risks: Injection Site Pain: You might feel mild soreness or see redness where the shot was given

This occurs through an increase in -adrenergic receptor expression in obese murine models

This can hinder drug effectiveness, as some drugs degrade in the acidic stomach environment or due to gut enzymes (82)

It is beneficial to hear about these possibilities before you are in desperate need of relief, giving you and your doctor time to consider them