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That this was not a cell culture-specific event was confirmed by its occurrence in leukemic patients undergoing treatment with high-dose 1-beta-D-arabinofuranosylcytosine and hydroxyurea

Gastroenterology 156(2):477-491 e471

doi: 10.1097/00000542-199612000-00028

In addition, studies suggest roles in angiogenesis, peripheral nerve outgrowth, antioxidant defense, and modulation of inflammatory activity, including in models of chronic pulmonary injury[2]

Romero-Figueroa MDS, Ramrez-Durn N, Montiel-Jarqun AJ, Horta-Baas G

HHcy can also contribute to neuronal toxicity through excitotoxic mechanisms [68] primarily by overstimulating N-methyl-D-aspartate (NMDA)-type glutamate receptors