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Hydroxocobalamin: The Long-Lasting Option Then theres hydroxocobalamin, a form of B12 thats a favorite for its staying power

Effects can last 1-4 weeks depending on your individual metabolism and B12 levels

Its effects are peripheral, working inside adipocytes and hepatocytes to restore NAD+-dependent metabolic flexibility

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Its contribution to weight loss is less straightforward than GLP-1's and is still an active area of research, but targeting both receptors simultaneously appears to produce greater weight reduction than GLP-1 alone, which is the basis for tirzepatide's dual mechanism