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Indeed, it was clearly shown that the antioxidant N-acetyl-L-cysteine (NAC) can inhibit eryptosis in vitro [116] and significantly prolong the half-life of circulating mouse erythrocytes in vivo [72] presumably by interfering with efferocytosis of eryptotic cells

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The high expression of drug efflux pump multidrug resistance 1 (MDR1) gene, and the MDR1-encoded P-glycoprotein (P-gp), an ATP-binding cassette transporter, are significantly implicated in the development of multidrug resistance (MDR) [32]