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Neuroscientists are working on a brain model to address this complexity

Adv Drug Deliv Rev 64:640665 Kannan R, Kuhlenkamp JF, Ookhtens M, Kaplowitz N (1992) Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence

The hemoglobin concentration served as normalization factor and was measured immediately after sampling in EDTA whole blood using the automated analyzer Celltac- (MEK 6450, Nihon Kohden, Qinlab Diagnostik, Weichs, Germany)