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Pham S, Ferguson GT, Kerwin E, Goodin T, Wheeler A, Bauer A

10.1038/emboj.2012.165 23 Kretz-RemyC.MehlenP.MiraultM

Clinical translation of ferroptosis modulators also faces significant bottlenecks, including bioavailability, limited tissue specificity, and potential toxicity or off-target [134, 135]

The pro-inflammatory cytokines (TNF-, IL-6, IL-8, E-selectin) and adhesion molecules (VCAM-1 and ICAM-1) stimulated by NF-B are implicated in the development of ECD [152, 153]

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