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In animal studies, it has been shown to decrease body fat and increase lean muscle mass

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J Control Release 297:3947

Huanglian-Houpo extract attenuates DSS-induced UC mice by protecting intestinal mucosal barrier and regulating macrophage polarization

Patients included in the study gave written informed consent and specimen collection was approved by the local Institutional Review Board of Charit University Medicine, Germany (EA4/019/12), the Ethics Committee of the University of Rostock, Germany (A 2009/34) and the Institutional Ethics Committee of the Medical University of Graz, Austria (24-402 ex 11/12)

Mihm et al, 1999), is involved in the oxidant stress-mediated regulation of numerous gene expression, particularly at the transcriptional level