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(Figure A) Step 3

Using this innovative approach, Cheng et al

Methionine is Essential amino acid for the synthesis of carrier proteins, and a lack of methionine leads to a reduction in Low-density lipoprotein synthesis and therefore the inability to transport TG out of the liver, leading to the accumulation of fatty liver [115] and steatohepatitis with similar histopathological features to human NASH [116,117,118]