glutathione brain function Changes in levels of the antioxidant in and blood across the age span of healthy adults: A systematic review Impaired Glutathione Synthesis in Neurodegeneration

Maes et al., 2011), and reduced activity of the antioxidant glutathione (GSH) in postmortem brain samples (Gawryluk et al., 2011)

PMID: 10657910

Genotypes of strains are described in Table 1

PMID: 11101407

Our group has an interest in glutathione and it is our hope to examine its various effects using scientific methods which will provide much needed guidance to physicians

Strategies aimed to increase cytosol GSH (e.g., NAC) may not be an optimal approach for boosting mGSH and therefore for treatment of SH or AD, as it would result in mainly increasing cytosol GSH without replenishing mGSH levels A new approach has been exploited recently in several contexts by the development of a series of cationic antioxidants targeted to mitochondria, including derivatives of the endogenous antioxidants ubiquinol (MitoQ), alpha-tocopherol (MitoVit E), and of the synthetic spin trap PBN (MitoPBN